Research Goal
We aim to understand the molecular mechanisms by which lipids regulate membrane protein activities and function and the impact of such lipid/protein assemblies in a subset of human diseases (cancer, neurodegenerative) and to map membrane protein-lipid interactome networks in the cell. The long-term objective is to obtain the cell blueprint that will help to understand and overcome biological processes and their consequences in human diseases. In short, knowing how to read the cell blueprint will tell us, for instance, how and what drives cancer and what part of the networks should be target before and after the network adapts and mutates.
Publications
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Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota
Nat Commun. 2024 Dec 30;15(1):10906. doi: 10.1038/s41467-024-55268-w. PMID: 39738071; PMCID: PMC11685898. -
Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases
Review. Int J Mol Sci. 2023 Jan 25;24(3):2384. doi: 10.3390/ijms24032384. -
Super-Resolution Microscopy to Study Interorganelle Contact Sites
Int J Mol Sci. 2022 Dec 5;23(23):15354 doi: 10.3390/ijms232315354 -
Identification of a New Cholesterol-Binding Site within the IFN-γ Receptor that is Required for Signal Transduction
Advanced science (2022); 9(11):e2105170. doi: 10.1002/advs.202105170 -
Super-Resolution Microscopy to Study Interorganelle Contact Sites
Int J Mol Sci. 2022:15354. doi: 10.3390/ijms232315354. PMID: 36499680. -
Role of Protein–Lipid Interactions in Viral Entry
Review, Adv Biol (Weinh). 6(3):e2101264 (2022) doi: 10.1002/adbi.202101264. -
Shedding light on membrane rafts structure and dynamics in living cells
Review, Biochim Biophys Acta Biomembr. 1864(1) 183813 (2022) doi:10.1016/j.bbamem.2021.183813 -
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA.
Sci Adv. 2021 Oct 15;7(42):eabj4565. doi: 10.1126/sciadv.abj4565.. PMID: 34652941 -
Super-Resolution Microscopy Using a Bioorthogonal-Based Cholesterol Probe Provides Unprecedented Capabilities for Imaging Nanoscale Lipid Heterogeneity in Living Cells.
Small Methods, 5, 2100430, (2021) doi: 10.1002/smtd.202100430 -
Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering
Advanced Science. 2003468. (2020) doi: 10.1002/advs.202003468 (2020)