Antibody Engineering & Membrane Biophysics in Disease

Research Goal

Our laboratory adopts an interdisciplinary approach to counteract the molecular mechanisms underlying disease by combining protein engineering with a deep understanding of the physical properties of cellular membranes.

One major research direction aims to enhance therapeutic antibody efficacy across a range of human diseases, including infectious diseases and cancer. We combine biophysical methods with molecular, structural and cell biology techniques, to elucidate mechanisms underlying antibody-antigen molecular recognition processes that occur within membrane microenvironments. Based on this knowledge, we apply protein engineering to optimize the activity of monoclonal antibodies. Our design strategy integrates biophysical characterization, in vitro functional assays in cellular systems, and preclinical studies in animal models. This iterative optimization process enables us to develop next-generation biological agents that surpass current therapies and advance the field of immunotherapeutics.

In parallel, our Membrane Biophysics in Disease research aims to uncover how the physical properties of cellular membranes influence human pathologies, with a particular focus on rare neurodegenerative disorders and viral infections. Through advanced fluorescence microscopy, we map the biophysical landscape of cell membranes, linking it to cellular dysfunction and exploring its potential for diagnostics, drug discovery and personalized medicine.