We are looking for candidates interested in pursuing a doctoral thesis in the laboratory of Dr. Guillermo Abascal-Palacios at Instituto Biofisika Basque Centre for Biophysics (CSIC-UPV/EHU), under a fully-funded FPI contract (4 years) from the Spanish Ministry of Science and Innovation (MICINN).
The “Structural Biology of DNA/RNA-Associated Machineries” laboratory focuses on the study of protein complexes that interact with DNA/RNA, with the aim of determining the molecular mechanisms responsible for their function. To achieve this goal, we carry out a combined process that includes protein complexes cloning and expression techniques, purification using chromatographic tools and their subsequent analysis using biophysical and structural biology methods such as cryo-electron microscopy (Cryo-EM) or X-ray crystallography. The ultimate goal is to determine a high-resolution molecular structure that shows enzymatic activity at the atomic level and that can contribute to the development of drugs against diseases such as colorectal cancer or certain neurological disorders.