We offer a postdoctoral position at the FluoroNanoTools lab at Instituto Biofisika (Leioa) under the supervision of Dr. Mónica Carril.
The research will focus on the development of bioorthogonal strategies to label membrane receptors in vivo. We aim to use ligand directed receptor covalent labelling, followed by biorthoogonal binding with suitably modified probes. Target receptors will be located at the neural membrane and could be AMPAR or TRP type, among others. We look for the combination of different strategies particularly those based on SuFEx reactions and those based on the reaction of tetrazines with trans-cyclooctene. The researcher will have to develop novel molecules to achieve the successful receptor labelling and the bioorthogonal binding with the selected probe, hence a deep knowledge of organic chemistry and/or medicinal chemistry is required. Background in bioorthogonal reactions will also be valued. The research is part of a collaborative interdisciplinary project that aims to neuromodulate the neuronal response.