Research Goal
Our group is interested in understanding the mechanisms at the origin of force generation, coordination and regulation in biological tissues during animal development. Our group uses an interdisciplinary approach, combining expertise in Drosophila genetics and molecular biology with high-resolution live imaging, biophysical analysis and modelling, with the aim of building a quantitative description of the mechano-chemical properties of the morphogenetic processes occurring during Drosophila Melanogaster embryogenesis.
Group members
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Jérôme Solon
Distinguished University Researcher | Ikerbasque Research Professor -
Tristan Béranger
Postdoctoral fellow -
Jone Isasti Sánchez
Postdoctoral Fellow -
Zugaitz Ortiz Bergara
PhD Student -
Lenka Backova
PhD Student -
Guillermo Bengoetxea González
PhD Student -
Aritz Durana Sarria
Research Technician -
Svana Rogalla
Marie Sklodowska-Curie Postdoctoral Fellow
Publications
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Chromatin compaction scaling with cell size follows a power law from interphase through mitosis
Biophys J. 2025 Nov 4;124(21):3678-3689. doi: 10.1016/j.bpj.2025.09.021. Epub 2025 Sep 18. PMID: 40968535. -
Label-free metabolic fingerprinting of motile mammalian spermatozoa with subcellular resolution
BMC Biol. 2025 Mar 24;23(1):85. doi: 10.1186/s12915-025-02167-1. PMID: 40128804; PMCID: PMC11934609. -
A transient contractile seam promotes epithelial sealing and sequential assembly of body segments
Nat Commun. 2025 Apr 29;16(1):4010. doi: 10.1038/s41467-025-58566-z. PMID: 40301337; PMCID: PMC12041241. -
Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.
Development (2023) 150 (9): dev200975. doi: 10.1242/dev.200975 -
Shaping the heart with mechanosensitive shrinking cells
Developmental Cell (2022), doi.org/10.1016/j.devcel.2022.02.016 -
Control of hormone-driven organ disassembly by ECM remodelling and Yorkie-dependent apoptosis.
Current Biology 31, 5261–5273, (2021) doi: 10.1016/j.cub.2021.09.057 -
A Compression Engine to Coordinate Tissue Elongation in the Embryo
Dev Cell. 55(3):256-258. (2020) doi: 10.1016/j.devcel.2020.10.013. (2020) -
In vivo force application reveals a fast tissue softening and external friction increase during early embryogenesis
Curr Biol. 2019 May 6;29(9):1564-1571. DOI: 10.1016/j.cub.2019.04.010 -
A new player in tissue mechanics: MicroRNA control of mechanical homeostasis
Dev Cell. 2019 Mar 11;48(5):596-598. DOI: 10.1016/j.devcel.2019.02.019 -
Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling
Dev Cell. 2018 Nov 19;47(4):453-463. DOI: 10.1016/j.devcel.2018.10.025 -
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
Sci Rep. 2018 Mar 26;8(1):5155. DOI: 10.1038/s41598-018-23408-0 -
Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita
Elife. 2018 Mar 14:7:e33807. DOI: 10.7554/eLife.33807