Research Goal
The main focus of the lab is on the molecular mechanisms of morphogenesis of lipid and cellular membranes at nanoscales. We want to understand how cells create, maintain and rapidly change the shape and topology of their membranes.
Main research interests:
– Conception of novel model membrane systems
– Functional reconstitution of membrane remodelling processes
– Characterisation of protein-membrane interactions
– Double membrane remodelling
Publications
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Sexual dimorphism on the acute effect of exercise in the morning vs. evening: A randomized crossover study
J Sport Health Sci. 2024 Dec 22:101021. doi: 10.1016/j.jshs.2024.101021. Epub ahead of print. PMID: 39716617. -
Fission of Double-Membrane Tubes under Tension
Biophys J. 2024 Oct 14:S0006-3495(24)00681-7. doi: 10.1016/j.bpj.2024.10.009. Epub ahead of print. PMID: 39410713. -
Membrane fission via transmembrane contact
Nat Commun. 2024 Mar 30;15(1):2793. doi: 10.1038/s41467-024-47122-w. -
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
Nat Commun 15, 52. 2024. Doi:10.1038/s41467-023-44413-6 -
Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1
PNAS (2022), doi.org/10.1073/pnas.2202391119 -
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress- induced mitochondrial fission.
Proceedings of the National Academy of Sciences Jul 2021, 118 (29) e2023079118, (2021) doi: 10.1073/pnas.2023079118 -
Nonlinear material and ionic transport through membrane nanotubes
BBA - Biomembranes 1863 (2021) 183677, (2021) doi: 10.1016/j.bbamem.2021.183677 -
Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes
Lab Chip. 20(15):2748-2755. (2020) doi: 10.1039/d0lc00451k (2020) -
Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers
Sci Rep. 9(1):7255. doi: 10.1038/s41598-019-43561-4. (2019) -
Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon
Nat Commun. 10(1):5327 (2019). doi: 10.1038/s41467-019-13327-7. (2019)