Research Goal
We use cryo-electron microscopy, combined with other structural and molecular biology approaches, to characterise macromolecular assemblies and viruses that are a current public health risk, like influenza, herpesviruses and bunyaviruses and their interactions with the host cell.
Publications
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Interactions between the 2C protein of FMDV and components of the viral replication machinery are mediated by ER-derived membranes
J Gen Virol. 2026 May;107(5):002244. DOI: 10.1099/jgv.0.002244. -
Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties
Sci Rep. 2026 Mar 24;16(1):14840 DOI: 10.1038/s41598-026-42810-7 -
Adhirons are efficient tools to guide antiviral ligand Discovery
Commun Biol. 2025 Nov 26;8(1):1755. doi: 10.1038/s42003-025-09137-x. PMID: 41298844; PMCID: PMC12686443. -
The architecture of membrane structures involved in hepatitis C virus genome replication revealed under close-to-native conditions by cryo-electron tomography
J Gen Virol. 2025 Nov;106(11). doi: 10.1099/jgv.0.002168. PMID: 41196697. -
Translational activity of 80S monosomes varies dramatically across different tissues
Nucleic Acids Res. 2025 Apr 22;53(8):gkaf292 doi: 10.1093/nar/gkaf292 -
Specialized ribosomes: integrating new insights and current challenges
Philos Trans R Soc Lond B Biol Sci. 2025 Mar 6;380(1921):20230377 doi: 10.1098/rstb.2023.0377 -
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
Matrix Biol. 2025 Apr;136:52-68 doi: 10.1016/j.matbio.2025.01.002 -
Lymphocytic choriomeningitis arenavirus utilises intercellular connections for cell to cell spread
Sci Rep. 2024 Nov 22;14(1):28961 doi: 10.1038/s41598-024-79397-w -
Insights into the structure of RNPs from segmented negative-sense RNA viruses
Structure. 2024 Aug 8;32(8):1027-1028 doi: 10.1016/j.str.2024.07.008 -
Exploiting the Affimer platform against influenza A virus
mBio. 2024 Aug 14;15(8):e0180424 DOI: 10.1128/mbio.01804-24 -
Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry
mBio. 2024 Jul 17;15(7):e0168423 doi: 10.1128/mbio.01684-23 -
Lymphocytic choriomeningitis arenavirus requires cellular COPI and AP-4 complexes for efficient virion production
J Virol. 2024 Mar 19;98(3):e0200623 doi: 10.1128/jvi.02006-23 -
Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry
Nat Commun. 2023 Sep 21;14(1):5885 doi: 10.1038/s41467-023-41205-w -
The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture
mBio. 2022 Aug 30;13(4):e0140522 doi: 10.1128/mbio.01405-22